San Francisco Giants at San Diego Padres odds, picks and predictions

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The San Francisco Giants (53-55) head down the coast to start a 3-game series with the San Diego Padres (61-50). First pitch from Petco Park is scheduled for 9:40 p.m. ET. Let's analyze Tipico Sportsbook's lines around the Giants vs. Padresodds with MLB picks and predictions.

San Francisco is 5-5 straight up (SU) in its last 10 games and swept a 2-game interleague series with the Bay Area neighbor Oakland Athletics Saturday-Sunday after losing 4 straight at home to the Los Angeles Dodgers.

San Diego is also 5-5 SU over its last 10 but has lost 4 consecutive outings, which includes being swept in a 3-game series at the Dodgers this past weekend.

Season series: The Padres lead 6-4 but the Giants have a plus-9 run differential in those meetings (45-36).

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Giants at Padres projected starters

LHP Alex Wood vs. LHP Blake Snell

Wood is 7-9 with a 4.42 ERA, 1.25 WHIP, 2.2 BB/9 and 8.9 K/9 in 106 IP over 21 starts.

  • Last start: Loss, 9-5, at home vs. the Dodgers Tuesday with 5 1/3 IP, 6 ER, 9 H, 1 HR, 1 BB and 6 K.
  • 2022 vs. the Padres: 1-1 with a 4.40 ERA (14 1/3 IP, 7 ER), 16 H, 1 HR, 4 BB and 18 K in 3 starts.

Snell is 4-5 with a 4.16 ERA, 1.33 WHIP, 4.6 BB/9 and 11.7 K/9 in 67 IP across 13 starts.

  • Last start: Win, 9-1, at home vs. the Colorado Rockies Wednesday with 6 IP, 1 ER, 4 H, 0 BB and 9 K.
  • 2022 vs. the Giants: 1 start - a 6-3 home win July 8 - with 6 IP, 1 ER, 3 H, 1 HR, 2 BB and 11 K.

Giants at Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:41 p.m. ET.

  • Money line (ML) : Giants +155 (bet $100 to win $155) | Padres -190 (bet $190 to win $100)
  • Run line (RL)/Against the spread (ATS) : Giants +1.5 (-135) | Padres -1.5 (+110)
  • Over/Under (O/U) : 7.5 (O: -107 | U: -115)

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Giants at Padres picks and predictions

Prediction

Padres 5, Giants 1

Money line

LEAN towards "flat-betting" or parlaying the PADRES (-190) with another similarly priced favorite for a better payout.

San Diego's ML price is a little expensive and we are getting the worst of the number. The Padres opened as -161 ML favorites per Pregame.com but have been steamed up by sharp action to the current number.

However, Snell's stuff is much nastier than Wood's and Snell has been finding his groove lately. He has won 3 straight starts, allowing just 2 earned runs over 17 innings during that span with a 21/3 K/BB rate. Also, Snell dominated the Giants when they last met in July.

San Diego's RL is my favorite look in this game but the PADRES (-190) is the right side.

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Run line/Against the spread

BETPADRES -1.5 (+110) because Snell has been shutting down opposing lineups and the Giants are 3-5 RL as road underdogs vs. left-handed starters and 13-28 RL vs. NL West foes.

Over/Under

LEAN UNDER 7.5 (-115).

There's a "Pros vs. Joe's" scenario in the betting market because more money is on the Under whereas more bets have been placed on the Over, according to Pregame.com.

It's wiser to follow the money in these situations since professional bettors wager a lot more dough than your average Joe. Also, the UNDER 7.5 (-115) being pricier insinuates it's the sharper side.

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